A study on the establishment of microbiome Atlas in Korean intestinal tract: A lifespan perspective.

This project aims to establish a lifespan gut microbiome atlas of healthy Korean individuals using shotgun metagenomes (about 500 individuals) and to compare it with the Dutch Microbiome Project. By integrating harmonized metadata, we will examine population-level differences in gut microbiome taxonomic and functional profiles in relation to age, diet, country, and ethnic background, while excluding major confounding factors. We will also investigate shared and distinct age-associated microbiome trajectories between Korean, Dutch, and other country individuals and use these findings to develop a microbiome-based aging prediction model. Analyses will include taxonomic composition, functional potential, antimicrobial resistance profiles, and microbiome age prediction. The data will be used solely for approved non-commercial academic research, with no re-identification or redistribution.