A systematical integrated analysis reveals the association between gut microbiota and mood disorder

Recently, increasing evidence has shown gut microbiota dysbiosis might be implicated in the brain diseases, especially in mood disorder, including major depressive disorder and biopolar disorder. Clinical studies have shown the changes in the gut microbial composition of depressed patients compared to healthy individuals, particularli in terms of diversity and the relative abundance of specific bacteria taxa. We collected metagenomics and 16S sequencing data to assembl and reconstruct gut ecological communities of different populations, in order to identify dominant bacterial species associated with different mood disorder phynotype. A systematical meta-analysis will be performed for all the collected public metagenomics data.  By comparing with the relevant studies in metabolomics, potential pathogenic metabolic pathways of disease will be detected. We hope our study could provide more theoretical support for the undterstand of gut-brain axis.