We found 1,670 gut QSPs via AI. Lead peptide GIVL (C. tyrobutyricum) inhibits α-glucosidase, improves glucose/insulin sensitivity in diabetic mice, and elevates SCFAs. To validate in human T2D, we will associate QSP strains with phenotypes (BMI, age, sex) and pathways (SCFA, carbohydrate metabolism). Plan: data access, download, QC, integration.
AI-driven discovery of hypoglycemic quorum sensing peptides from the human gut microbiome
Year of approval
2026
Institute
DUT - Faculty of Chemical, Environmental and Biological Science and Technology (CHN)
Primary applicant
Ren, S.