Antagonistic pleiotropy of the ApoE genotype in memory

We aim to understand how a specific gene called ApoE influences memory function and impacts our brain health. What is intriguing is that the ApoE4 variant of this gene, despite being associated with a higher risk of developing Alzheimer’s disease later in life, remains in our population. Some findings in younger people have suggested that ApoE4 may actually be beneficial for memory. This phenomenon, called antagonistic pleiotropy, is potentially of great interest. By using novel, computerized memory tests, we have uncovered subtle changes in memory that may relate to ApoE4. By partnering with Lifelines Biobank and engaging a diverse group of participants, we intend to understand better why this seemingly "troublesome" gene persists in the population. Unraveling this puzzle could hold the key to understanding memory disorders and designing interventions that benefit us all.