Associations of antibody glycosylation with healthy aging and inflammaging

Antibody glycosylation critically modulates immune activation. It changes with age and associates 
with inflammatory and metabolic health. This project aims to characterize IgG and IgA glycosylation 
profiles in 800 Lifelines participants selected to represent a broad range of chronological and 
biological ages, and to examine how these profiles associate with blood-based biomarkers, disease 
status, dietary inflammatory index, and lifestyle factors. This work will contribute to the 
understanding of immune changes in the context of healthy ageing.