Stressful life events and negative economic shocks may damage health, but the deterioration is
hard to observe with traditional measures (e.g., diagnoses, prescriptions, functional limitations).
The body absorbs the shock long before it surfaces as illness or care, and biological age offers a
reliable pre-clinical alternative. Linking Lifelines to Dutch administrative registers, we study how life
events (e.g., bereavement, severe illness of a relative, childbirth, separation), socioeconomic
shocks (e.g., mass layoffs, job loss, employment insecurity) and (related) mental health issues
causally affect physical health, measured via accelerated ageing, and, in the other direction, how
accelerated ageing affects later outcomes.
Determinants and consequences of biological ageing: life stressors, socioeconomic shocks and mental health
Year of approval
2026
Institute
Università della Svizzera italiana (SUI)
Primary applicant
Mazzonna, F.