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Elucidating Gut Microbiome Signatures Associated with Metabolic

The primary objective of this research project is to investigate potential associations between microbial community characteristics, or specific microorganisms, and host metabolite profiles. We aim to explore whether links exist between the presence or abundance of certain microbes (or overall community structures) and the levels of various metabolites.

Our research seeks to identify if there are discernible patterns in these microbe-metabolite relationships. By analyzing microbial data alongside metabolomic data, we hope to uncover significant correlations and interaction patterns.

Understanding these connections and identifying consistent patterns is crucial. It holds the potential to help identify core microbial members or key metabolic mechanisms that significantly impact host health. Elucidating these microbe-metabolite associations could ultimately contribute to a better understanding of biological systems relevant to health and disease, potentially paving the way for strategies aimed at health improvement by targeting key microbes or pathways.

Year of approval

2025

Institute

SMU Zhujiang Hospital

Primary applicant

Zhang, J.