ENV-LIFE: Environmental noise and air pollution in relation to cardiovascular and mental health - a longitudinal Lifelines cohort study

ENV-LIFE will investigate whether long-term residential road-traffic noise and ambient 
air pollution are associated with cardiovascular and mental-health outcomes in the 
Lifelines cohort. Longitudinal analyses will combine existing environmental exposure 
data with repeated disease, physiological, laboratory, sleep, stress and psychiatric 
phenotypes. In participants with existing omics data, exploratory multi-omics analyses 
will evaluate biological signatures related to environmental exposures and health 
outcomes. Secondary analyses will assess co-exposure, sex and socioeconomic 
effect modification, and, through CBS linkage, cause-specific mortality and additional 
socioeconomic registry information where feasible.