Genetic and environmental interactions in glucose metabolism deterioration under obesity-related metabolic heterogeneity

This project aims to investigate how genetic susceptibility and environmental exposures jointly contribute to worsening glucose metabolism in the context of obesity-related metabolic heterogeneity. Using cohort data, we will classify individuals into metabolic obesity phenotypes and examine their associations with fasting glucose, HbA1c, insulin resistance, and incident type 2 diabetes. We will further assess gene–environment interactions involving polygenic risk and lifestyle or environmental factors, including diet, physical activity, and other relevant exposures. The study seeks to clarify heterogeneous metabolic trajectories and identify high-risk subgroups for early prevention.