Guts to be depression: Reflection of depressive symptoms in the gut microbiota from a multi-cohort meta-analysis (G2BD!)

In clinical practice and real-world settings, depressive symptoms induce functional impairments and health burden across individuals who may or may not meet the diagnostic criteria for mood disorders. While robust gut microbial differences associated with major depressive disorder have been reported, the extent to which these differences are corresponding to symptom burden received relatively less attention. In this project, we will perform a harmonized meta-analysis across large population cohorts to identify robust, association signals between gut microbial features and depressive symptoms, integrating 16S, shotgun metagenomics, and symptom measurements