Longitudinal Associations Between Physical Activity and Obesity Risk: An OBCT Study Using the Lifelines Cohort

Obesity remains a major public health challenge in Europe, yet evidence on how sustained physical 
activity over time influences obesity risk is scarce, as most studies rely on single, baseline physical 
activity measures. This limitation hampers the accurate identification of stable dose-response 
relationships essential for preventive guidelines. Utilizing repeated physical activity assessments 
from the Lifelines cohort, our study will precisely examine the longitudinal associations between 
physical activity levels and total and abdominal obesity, informing tailored preventive strategies that 
consider age, sex, and socioeconomic status population subgroups.