Molecular determinants of healthy aging

Aging is highly heterogeneous: people of the same chronological age differ markedly in health, function, and disease risk because of complex genetic, molecular, and environmental influences. This study will integrate genetic, metabolomic, epigenetic, and proteomic data to identify signatures of resilience, stability, and early dysregulation. Building on our long-standing work defining optimal biological ranges and quantifying departures from them, we will assess dysregulation across multiple molecular layers and examine genetic buffering as a mechanism of resilience. These analyses will clarify how biological systems maintain or lose homeostasis with age and support interpretable biomarkers of healthy aging.