Predicting Healthy or Unhealthy Aging through the Gut Microbiota Association Between Diet and Gut Microbiota

The project aims to identify age-related changes in the gut microbiome and analyze key archaeal, bacterial, fungal, and viral species during this process, along with their interactions within the ecological network. First, we will assess the changes in the gut microbiome during the aging process and the characteristics of gut microbes in different age groups. Next, we aim to develop a microbiome-based aging clock and use it to explore its relationship with healthy or unhealthy aging. Additionally, we plan to compare the new model with other existing aging models, such as PhenoAge, among others. Furthermore, we intend to investigate the effects of diet on the gut microbiota and how to reverse unhealthy gut microbiota.