PRS in cardiovascular disease and risk factors

Cardiovascular disease is one of the leading causes of death worldwide. Understanding how these diseases develop and how they could be predicted could improve preventive healthcare. Waist circumference is a well-known risk factor for cardiometabolic disease and understanding the genetics behind how fat accumulation and distribution changes over time in males and females is important. Atrial fibrillation is associated with many serious comorbidities such as stroke and benefits from early detection. Currently, genetics are not implemented in screening. Therefore, we want to understand the genetic basis of these two risk factors by using PRS to predict them.