Role of Air Pollution in the Evolution of Chronic Kidney Disease in Lifelines

Air pollution, especially fine particulate matter (PM2.5), can enter the bloodstream and cause oxidative stress, inflammation, and cellular damage. While its links to cardiovascular, respiratory, and metabolic diseases are well established, its role in chronic kidney disease (CKD) progression is less studied, particularly in long-term population cohorts. In the Netherlands, where CKD affects about 6% of people, this study we aim to examine the association between long-term PM2.5 exposure and evolution of CKD in North-Holland using Lifelines cohorts. We aim at exploring how green space, urban density, and neighbourhood socioeconomic status may influence susceptibility to pollution-related kidney damage.