Unraveling the Dynamic Interplay of Environmental Factors, Health Trajectories, Relationships, and Multi-Phenotype Analysis in Type 2 Diabetes and Comorbid Conditions

Environmental factors significantly contribute to cardiovascular and metabolic non-communicable diseases like obesity and type 2 diabetes. This study examines their impact on health outcomes, underscoring the need for evidence-based predictions. We focus on critical health trajectories influenced by maternal obesity during pregnancy, exploring individual and societal interventions through the Health Capital paradigm. Furthermore, we uncover shared genetic links between metabolic, psychological, cancer phenotypes, shedding light on potential causal relationships. Additionally, we delve into the gut-brain axis's role in environmental health outcomes and explore genetic associations in reproductive health, aiming to bridge gaps in understanding for targeted interventions and policy decisions.