Unraveling the microbiota-immune axis and immune response dynamics in inflammatory bowel disease

The human gut contains trillions of bacteria and other microorganisms that can be both beneficial and detrimental to our health. Our immune system is equipped to sense these gut microbes and controls the interactions between ourselves and residing microorganisms. Some immune responses to microbes may contribute to health, whereas others might trigger or exacerbate intestinal diseases such as inflammatory bowel diseases (IBD). Using two innovative sequencing technologies, we aim to comprehensively examine the structure of immune sensing T- and B-cell receptors and their interactions with gut microbes, ultimately aimed to better understand the immunological processes involved in the development of IBD