Heb je een vraag? Neem gerust contact met ons op.


Telefoon: 050 - 36 11 113 (werkdagen van 8.00 - 17.00 uur)



Do you have a question regarding working with Lifelines? Please contact us, we're happy to help you.

Contact us


We voorzien media graag van informatie en we behandelen graag verzoeken voor interviews, opnames en beeldmateriaal.

Stuur een e-mail


Childhood maltreatment and the risk of impaired glucose metabolism or type 2 diabetes in young adults: findings from the Lifelines Cohort Study

Background: This study examined the associations between childhood maltreatment and the risk of developing impaired glucose metabolism (IGM) or type 2 diabetes in young adults aged 18 to 35.
Methods: Participants (N = 8,506) from the Lifelines Cohort Study without IGM or diabetes at baseline (2007 to 2013) were included. Self-reported childhood maltreatment was assessed using the Childhood Trauma Questionnaire (CTQ), with a total score and subscale continuous scores (ranging from 5-25) for emotional neglect, physical neglect, emotional abuse, physical abuse, and sexual abuse. Incident IGM/type 2 diabetes status (IGM/T2D) was assessed by hemoglobin A1c levels (>5.7%) during a follow-up laboratory visit (2014-2017). 
Results: There were 219 (2.6%) cases of IGM and 4 (0.05%) cases of T2D during the follow-up period. The CTQ total score and sexual abuse subscale were associated with an increased risk of IGM/T2D in unadjusted analyses (RR= 1.03 [95% CI = 1.00, 1.03], p = 0.009 and RR= 1.07 [95% CI = 1.02, 1.12], p = 0.007, respectively). After adjusting for sociodemographic and health/lifestyle covariates and follow-up time, only childhood sexual abuse remained significantly associated with IGM/T2D (RR = 1.05 [96% CI = 1.01, 1.10], p = 0.024). The association remained when additionally accounting for depression and anxiety covariates (RR = 1.05 [96% CI = 1.00, 1.09], p = 0.042). 
Conclusions: A one-unit increase in the sexual abuse subscale score was associated with a 5% increased risk of IGM/T2D. Research investigating the mechanisms that link childhood sexual abuse with an increased risk for IGM/T2D is needed. 
Keywords: adverse childhood experiences; anxiety; childhood maltreatment; depression; impaired glucose metabolism; prediabetes; type 2 diabetes

Year of publication



Journal of Health Psychology


DeschĂȘnes, S.S.
Nearchou, F.
McInerney, A.
Schmitz, N.
Pouwer, F.
Nouwen, A.

Full publication

Click here to view the full publicationClick here to view the full publication