Heb je een vraag? Neem gerust contact met ons op.


Telefoon: 050 - 36 11 113 (werkdagen van 8.00 - 17.00 uur)



Do you have a question regarding working with Lifelines? Please contact us, we're happy to help you.

Contact us


We voorzien media graag van informatie en we behandelen graag verzoeken voor interviews, opnames en beeldmateriaal.

Stuur een e-mail


Genomics research of lifetime depression in the Netherlands: The BIObanks Netherlands Internet Collaboration (BIONIC) project

The BIONIC (BIObanks Netherlands Internet Colalboration) project represents a nation-wide 
collaboration among population cohorts in the Netherlands. Within this collaboration we developed 
a standardized online instrument for the assessment of DSM-based diagnosis of major depressive 
disorder (MDD), which was validated and showed a twin family-based heritability of 35%. Next, 13 
cohorts in the Netherlands collected MDD data and agreed to share the phenotype and genotype 
data for genome-wide association studies (GWAS), enabling mega- and meta-analyses. Phenotype 
data include MDD diagnoses and also data on sociodemographics, lifestyle and other mental health 
information. We have established a database of N = 132,850 adults. The lifetime prevalence of MDD 
in this sample is 18.1% which complies with prevalence estimates of other studies in the 
Netherlands. Currently, N = 66,648 individuals in the BIONIC set also have genome-wide SNP data. As 
different cohorts obtained SNP data from different arrays, we developed a strategy to optimally 
combine array data and implemented a centralized pipeline for genotype imputation that we 
describe in this paper, together with the phenotypic sample characteristics. 
Key words: national cohort studies, MDD assessment, GWAS resource

Year of publication



Twin research and human genetics


Huider, F.
Milaneschi, Y.
Hottenga, J.J.
Bot, M.
Rietman, M.L.
Kok, A.Al>

Full publication

Click here to view the full publicationClick here to view the full publication